Beta
31438

Cardiac troponin elevation as an evidence of neurogenic myocardial dysfunction in patients with head trauma

Article

Last updated: 22 Jan 2023

Subjects

-

Tags

-

Abstract

Background: cardiac dysfunction is frequently observed after severe traumatic brain injury (sTBI), however its significance is poorly understood. Our study sought to elucidate the association of cardiac troponin I (cTnI) elevation with all cause in-hospital mortality following isolated sTBI (brain AIS ≥ 3 and admission GCS ≤ 8, no AIS ≥3 to any other bodily regions).
Patients and methods: After approval of this study from local ethical committee, and obtaining written informed consent from relatives, head trauma patients will be enrolled in this observational  prospective study. study was conducted in the 10-bed trauma-surgical ICU in Sohag university hospital , Fifty patients with isolated TBI , were consecutively included between January 2015 and February 2017.
Results: our study validated cTnI as a novel biomarker and independent predictor of all cause in-hospital mortality in patients with TBI. these findings have several implications. First, cTnI assay should be considered in patients with sTBI even in absence high suspicion of cardiac injury. Second, cTnI is a sufficiently prognostic biomarker of mortality in patients with sTBI. Third, cTnI elevation in patients with sTBI must be treated with caution.
Conclusion: cTnI level was a significant indicator for stress cardiomyopathy , severity of trauma calculated by RTS had no relation with incidence of stress cardiomyopath . Our study provided important insights to the heart-brain interactions following TBI and possible schemes for subsequent optimization of management of these patients.

DOI

10.21608/smj.2018.31438

Authors

First Name

Abdelrahman

Last Name

Abdelrahman

MiddleName

Hassan

Affiliation

Department of Anesthesiology, Faculty of Medicine, Sohag University.

Email

abdelrahman-abdelrahman@med.sohag.edu.eg

City

Sohag

Orcid

-

First Name

Wesam

Last Name

Abdgalil

MiddleName

-

Affiliation

Department of Anesthesiology, Faculty of Medicine, Sohag University

Email

abdeljilwesam@yahoo.com

City

Sohag

Orcid

-

First Name

Al haitham

Last Name

Taha

MiddleName

Mohamed

Affiliation

Department of Anesthesiology, Faculty of Medicine, Sohag University.

Email

alhaithmmohamed@med.sohag.edu.eg

City

Sohag

Orcid

-

Volume

22

Article Issue

3

Related Issue

4807

Issue Date

2018-10-01

Receive Date

2018-08-05

Publish Date

2018-10-01

Page Start

95

Page End

108

Print ISSN

1687-8353

Online ISSN

2682-4159

Link

https://smj.journals.ekb.eg/article_31438.html

Detail API

https://smj.journals.ekb.eg/service?article_code=31438

Order

12

Type

Original Article

Type Code

785

Publication Type

Journal

Publication Title

Sohag Medical Journal

Publication Link

https://smj.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023