Introduction: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by the development of synovitis, which damages cartilage, bone, ligaments, and tendons. US is available, noninvasive, and relatively inexpensive bedside imaging method with high patient acceptability. This technique is more sensitive and reproducible than clinical evaluation in assessing joint inflammation. Power Doppler (PD) US detect flow from small vessels and low velocity flow at the microvascular level. PD US detects indirect signs of increased vascularization associated with soft tissue musculoskeletal inflammatory and infectious diseases and enteritis in spondyloarthropathies.
Aim of the work: Follow up of RA patients for assessment activity by gray scale and PD during 12 months.
Patients and Methods: longitudinal observational study included 30 Adult patients fulfilling 2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism criteria will be included in this study.
Results: There was high significant difference between different times of follow up (start, 6, 12 months) as regards count of swollen joints, tender joints, VAS, and DAS (p value <0.001) as mean value of them decreased significantly from start up to 12 months. There was high significant difference between different times of follow up (start, 6, 12 months) as regards RT US gray scale count, LT US gray scale count, Total US gray scale count, and Total US gray scale number  (p value <0.001) as mean value of them decreased significantly from start up to 12 months
Conclusion: The combination of grey scale US and PD could be used as a sensitive and reliable non-invasive and widely available method complementary to standard clinical assessment for evaluating rheumatoid synovial inflammation in daily management and clinical trials.