Objectives:The aim of this study is to asses prevalence & clinical outcome of hyperparathyroidism among CKDpatients either on dialysis or not in Sohag University Hospital 1.To estimate serum intact parathormone(iPTH) and other biochemical parameters (calcium, inorganic phosphate, urea and creatinine)in CKDpatients2. To compare and find out correlation between serum intact parathormone and biochemicalparameters in the study group.
Patients &Methods: For the study of 5 stages of Chronic Kidney Disease(CKD) totally 100 patients in different stages inthe age group of 20-60 years were taken. Serum parathormone and other biochemical parameters were estimated using standard methods.Pelvi-abdominal ultrasonography,Plain x-ray,ECG & Echocardiography were also done.
Results:66 patients (66.00%) with PTH values above the normal range (hyperparathyroidism) (>72 pg/ml), with mean PTH = 481.92 ± 608.05,   and this is the prevalence rate of secondary hyperparathyroidism in the study population. The serum PTH levels were higher even in early stages of CKD and the higher values are directly related to the stage of CKD.  In the study, Serum phosphorus was found to be significantly positively correlated to PTH both in the total study population and in patients with hyperparathyroidism.The PTH was found to be significantly negatively correlated with serum total and ionized calcium of the patients, both in the total study population and in patients with hyperparathyroidism.Also the findings of this study as regard echocardiography in CKD patients;Left ventricular dysfunction was the commonest cardiovascular abnormality. LVH was the most common echocardiographic abnormality in CKD cases. Diastolic function was deranged in more number of patients as compared to systolic function in patients with CKD.
Conclusion: The estimation of serum PTH and other biochemical parameters can help to diagnose the secondary hyperparathyroidism in the early stage of CKD which inturn has advantage to manage the patients of CKD accordingly to prevent the future complications.