Introduction: Diabetes mellitus (DM) is a chronic metabolic disease of high morbidity and mortality, which has become a public health problem. Musculoskeletal complications occur with DM and significantly compromise the patients' quality of life. The most common musculoskeletal manifestations of diabetes mellitus are Muscle cramps, Muscle infarction, Loss of deep tendon reflexes, Peripheral neuropathy, Reflex Sympathetic Dystrophy Syndrome, Stiff Hands Syndrome, Neuropathic joints, Carpal tunnel syndrome, Adhesive capsulitis of the shoulder, Tenosynovitis, Diffuse Idiopathic Skeletal Hyperostosis and Dupuytren contracture.                                                                                                                
Aim of the work: investigate the association between DM and musculoskeletal disorders in sohag governorate population.
Patients and Methods: Cross sectional clinical study included 200 adults with definite diagnosis of Diabetic patient with musculoskeletal disorder recruited from patients attending to the outpatient clinic of the Diabetes & internal medicine, Sohag University Hospital. All of the patients selected and underwent: Complete clinical assessment, Careful general, musculoskeletal examination, Laboratory assessment.
Results: 53% of our diabetic cases had muscloskeletal manifestations.
Conclusion: about 53% of the type 2 diabetics suffer from musculoskeletal manifestations. The most common manifestations are seen in carpel tunnel syndrome which seen in 30% of our cases.