Background:Dexmedetomidine, a highly selective α2-adrenoceptor agonist, is widely used in clinical anaesthesia, and intensive care unit. The aim of this study is to evaluate the hemodynamic and analgesic effects of dexmedetomidine in major abdominal surgeries.
Patients and methods: 40 patients for radical cystectomy in the age range of 40 – 65 years participated in this prospective, randomized, double blinded, placebo controlled clinical study. Patients were randomly assigned to receive either Dexmeditomidine (Dex group) or normal saline (0.9%) (Control group).patients hemodynamics, Recovery profile, and Pain intensity were evaluated.
Results Intraoperative mean arterial pressure and heart rate were significantly lower but stable in Dex group. Patients in Dex group had lower VAS scores.
Conclusion:Dexmedetomidine is effective in attenuating hemodynamic response to surgical stimulation. Patients in Dex group experienced less postoperative pain.