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40762

The effect of rotenone on the dopaminergic cells of the substantia nigra of the midbrain in the adult male albino rats

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Last updated: 04 Jan 2025

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Abstract

Background aims.  Rotenone is a widely used insecticide has a neurodegenerative effect on the dopaminergic cells of substantia nigra (SN) of midbrain producing Parkinsonism. The aim of this study is to study the effects of rotenone when injected subcutaneously on the dopaminergic cells of the substantia nigra of the midbrain.Methods. The effects of rotenone on the SN of midbrain and the were determinedhistopathologically, immunohistochemically, and by transmission electron microscopy. Results. Subcutaneous rotenone produced Parkinsonism through producing degeneration of the dopaminergic cells of SN of the midbrain. Conclusion. These results indicate that, rotenone has a neurodegenerative effect on the dopaminergic cells of the substantia nigra of the midbrain producing parkinsonism

DOI

10.21608/smj.2017.40762

Keywords

Dopaminergic neurons, Neurodegeneration, parkinsonism, Rotenone, Substantia nigra

Authors

First Name

MOHAMMED

Last Name

mahmod

MiddleName

ABDEL-RAHMAN

Affiliation

Department of Anatomy Faculty of Medicine, Sohag University

Email

mohamed_gouda@med.sohag.edu.eg

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Orcid

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First Name

RANIA

Last Name

A. GALHOM

MiddleName

-

Affiliation

2Department of Anatomy & Embryology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

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City

-

Orcid

-

First Name

, WAEL

Last Name

NASR EL-DIN

MiddleName

AMIN

Affiliation

2Department of Anatomy & Embryology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt,

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Orcid

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First Name

MONA H.

Last Name

ALI

MiddleName

MOHAMMED

Affiliation

Department of Anatomy, Ibn Sina National College for Medical Studies, Jeddah, Saudi Arabia.

Email

-

City

-

Orcid

-

First Name

SAAD

Last Name

ABDEL-HAMID

MiddleName

ABDEL-HAMID

Affiliation

-

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-

Orcid

-

Volume

21

Article Issue

1

Related Issue

4801

Issue Date

2017-01-01

Receive Date

2016-11-08

Publish Date

2017-01-01

Page Start

247

Page End

257

Print ISSN

1687-8353

Online ISSN

2682-4159

Article File

SMJ_Volume 21_Issue 1_Pages 247-257.pdf

PDF . 233.1kB

Link

https://smj.journals.ekb.eg/article_40762.html

Detail API

https://smj.journals.ekb.eg/service?article_code=40762

Order

25

Type

Original Article

Type Code

785

Publication Type

Journal

Publication Title

Sohag Medical Journal

Publication Link

https://smj.journals.ekb.eg/

MainTitle

The effect of rotenone on the dopaminergic cells of the substantia nigra of the midbrain in the adult male albino rats

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Article

Created At

22 Jan 2023