Introduction Facial cellulitis and abscesses are common in public health problems and early recognition and management is critical, as they are becoming more severe with a noticeable increase in hospitalization. Aim of work detection of factor affecting outcome in the management of cervicofacial infections and complication to reduce associated mortality and morbidity. Patient and method This study was a prospective study which was conducted at Sohag University Hospital, General Surgery Department. It included patients with cervicofacial infection of odontogenic or non-odontogenic origin either localized or diffuse infection attended to at the Oral and Maxillofacial Surgery Clinic or the Accident and Emergency Unit from October 2016 to October 2017. Results This study included 35 cases, the submandibular space was the most common single site affected (11-34.29%), followed by bilateral or multi- space involvement presented (13-37.14%) of study patients, Diabetes mellitus was the most common associated co- morbidity among study population (12-34.29%), and other systemic diseases (6-17.14%). Conclusion Diabetes, bad general condition, impaired laboratory parameters including an elevated blood sugar level and metabolic acidosis at time of admission were found to be significant risk factors for development of post intervention complications and/ or delayed recovery.