Obesity is a major global health issue. Most obese patients develop metabolic syndrome, a cluster of clinical features characterized by hypertension, insulin resistance and dyslipidemia this pre-diabetic condition has recognized as an independent risk factor for cardiovascular diseases, particularly hypertension, atherosclerosis and diabetic cardiomyopathy. MSC can differentiate into many mesenchymal cells as cardiomyocytes. The application of MSCs in the treatment of DC in recent years offers promising results. Stem cell therapy has emerged as a promising strategy for the treatment of dead myocardium, directly or indirectly, and seems to offer functional benefits to patients.Recently, a substantial number of clinical trials have proven that stem cell therapy is safe. Infusion of bone marrow-derived stem cells (BMCs) represents the greatest number of clinical studies for MI. This review highlights the use of mesenchymal stem cells in metabolic syndrome and diabetic cardiomyopathy