Cell death is a highly organized pathophysiological process, fundamental for normal life and development. Balance between cell proliferation and cell death is essential for the development and maintenance of multicellular organisms. Despite the different causing stimuli, cell death mode typically follows one of two patterns.The first is programmed cell death (PCD) while the second pattern is necrosis. PCD include more than 15 types, the most common types are three include; apoptosis, autophagic cell death and programmed necrosis (necroptosis). Disorders of either process have pathologic consequences and can lead to disturbed normal embryogenesis, neurodegenerative diseases, or cancer development. This review article discusses the apoptotic cell death types, molecular pathwayandmorphological changes.