SBP is a frequent and severe complication in patients with cirrhosis and ascites. diagnosticparacentesis is used commonly to investigate the prescence of  SBP. The aim of this study was to evaluate Therole of ascitic fluid lactoferrin as reliable biomarker for the presence ofPMNs and detection of SBP in patients with cirrhosis.ascitic fluid lactoferrin level is much higher among patients with SBP compared to those without SBP.The usefulness of ascetic fluid lactoferrin is still uncertain to rule out SBP because the small number of cases.