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45024

Teratogenic effects of aflatoxin in Rabbits (Oryctolagus cuniculus)

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Last updated: 04 Jan 2025

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Abstract

This study was conducted to determine the teratogenic effects of aflatoxin B1 (AFB1) in balady rabbits. The female animals divided into two groups control and treated, each group contained three dams. A dose of 0.05mg /kg/day AFB1 was administered by gastric intubation to pregnant rabbits on the 6th–18th day of pregnancy. The fetuses were obtained through the uterine incision at 29th day of gestation. The lengths and weights of the fetuses as well as absolute organs weights were measured, revealing the statistically significant differences between the two groups (p<0.001).The observed gross anomalies included wrinkled skin, enlarged eye socket and microphthalmic eyes. The heart of treated group showed reduction in size with wide ventricular lumen and shallow inter ventricular groove. The characteristic fetal histopathological findings were vaccuolation and distortion of hepatic cord pattern. The renal tubular epithelium was vacuo- lated and their lumen were occluded with casts. The eye lids revealed less number of hair follicles. Regarding, the skeletal anomalies there were incomplete ossification in some of the skull bones, the lami- nae of the vertebral arches throughout the vertebral column remain cartilaginous. The sternum was incompletely ossified. The 2nd phalanx, carpus, extremities of metacarpi had no cartilaginous drafts. The central and distal tarsal rows as well as extremities of metatarsi remained car- tilaginous..

DOI

10.21608/jva.2013.45024

Keywords

Aflatoxin B1 (AFB1), Rabbits, teratogenicity, Ossification, histopathology

Authors

First Name

S.

Last Name

El-Nahla

MiddleName

M.

Affiliation

Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt;

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Orcid

-

First Name

H.

Last Name

Imam

MiddleName

M.

Affiliation

Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt;

Email

-

City

-

Orcid

-

First Name

E.

Last Name

Moussa

MiddleName

A.

Affiliation

Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt;

Email

-

City

-

Orcid

-

First Name

A.

Last Name

Ibrahim

MiddleName

M.

Affiliation

Department of pathology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt;

Email

-

City

-

Orcid

-

First Name

A.

Last Name

Ghanam

MiddleName

R.

Affiliation

Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt;

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-

City

-

Orcid

-

Volume

6

Article Issue

2

Related Issue

6966

Issue Date

2013-10-01

Receive Date

2013-06-04

Publish Date

2013-10-01

Page Start

67

Page End

85

Print ISSN

1687-9988

Online ISSN

2357-0504

Article File

JVA_Volume 6_Issue 2_Pages 67-85.pdf

PDF . 1.4MB

Link

https://jva.journals.ekb.eg/article_45024.html

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https://jva.journals.ekb.eg/service?article_code=45024

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Original Article

Type Code

782

Publication Type

Journal

Publication Title

Journal of Veterinary Anatomy

Publication Link

https://jva.journals.ekb.eg/

MainTitle

Teratogenic effects of aflatoxin in Rabbits (Oryctolagus cuniculus)

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Article

Created At

22 Jan 2023