Abstract.
This study was attempted to figure out the hypolipidemic and hypoglycemic effects of cinnamon (CIN) and sesame oil on rats fed high-fat diet (HFD). It was conducted on 36 rats, divided into control (12) and high fed diet (24) for 7 weeks, and then 6 animals from each group were killed for collection of samples. The remaining rats of HFD group (18) were subdivided into three subgroups (6 rats for each): recovery (fed standard diet only), Cinnamon (CIN) group and sesame group. Lipid profile and glucose hemostasis, TNF-αand C-reactive protein (CRP) were detected in all groups. The histology and immunohistochemistry of liver with nuclear factor kappa B (NF-kB), in addition to DNA fragmentation assay were carried out. High fat diet (HFD) rats showed an increase in choles- terol, triglycerides, LDL-c, glucose, insulin resistance. Also, CRP and TNF-α in serum and immune- expression of NF-kB in liver were elevated. Both CIN and sesame were completely restored LDL-c, glucose, HOMA -IR, CRP and TNF-α and partially restored cholesterol, triglyce- rides (TG) and insulin resistance. CIN enhances HDL-C level. Histologically, lipid droplets, inflammatory and Kupffer cells were increased in HFD. The histological and immunohisto- chemical profiles were improved in CIN group and sesame group but CIN was much better than sesame. No DNA fragmentation was observed in any of the five groups, which indicated hypolipidemia however; CIN improves the histological profile more than se- same oil.