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37156

Effects of Organic and Inorganic Mercury on the Apoptosis of the Neural Tube Cells of Zebrafish Embryos (Danio rerio)

Article

Last updated: 04 Jan 2025

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Abstract

Abstract In this study, we tested the hypothe- sis that mercury-induced develop- mental toxicity was mediated via ec- topic occurrence of apoptosis during embryonic development. We em- ployed microscopy to acquire images of whole-mount staining of apoptotic cells in zebrafish embryo exposed to 5, 10, 50, 80, 100, 150 ppb me hg and 50, 100, 200, 300, 400, 500 ppb hg cl from 5 hours post fertilization (hpf) to 48hpf. In mercury-treated embryos with var- ying degrees of gross developmental malformations, significantly higher numbers of apoptotic cells were de- tected with this method. In the de- generating neural tube of mercury treated embryos apoptotic cells were detected, while in the healthy neural tube of the untreated controls no apoptotic cells were found. The per- centages of apoptotic cells increased with the dose in both Me hg and Hg cl exposure. Exposure to mercury, therefore, induced ectopic apoptosis at 84 hpf.

DOI

10.21608/jva.2017.37156

Keywords

Keywords: mercury, apoptosis, Zebrafish embryos

Authors

First Name

Said

Last Name

Hassan

MiddleName

A.

Affiliation

Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.

Email

shassan1978@gmail.com

City

Ismailia

Orcid

-

First Name

L.

Last Name

Abbott

MiddleName

C.

Affiliation

Department of Veterinary Integrative Biosciences, College of Veterinary Medicine, Texas A&M University USA

Email

-

City

-

Orcid

-

First Name

E.

Last Name

Moussa

MiddleName

A.

Affiliation

aDepartment of Anatomy and Embryology, Faculty of Veterinary Medicine, Suez Canal University

Email

-

City

-

Orcid

-

Volume

10

Article Issue

1

Related Issue

6006

Issue Date

2017-06-01

Receive Date

2017-03-12

Publish Date

2017-06-01

Page Start

49

Page End

59

Print ISSN

1687-9988

Online ISSN

2357-0504

Link

https://jva.journals.ekb.eg/article_37156.html

Detail API

https://jva.journals.ekb.eg/service?article_code=37156

Order

5

Type

Original Article

Type Code

782

Publication Type

Journal

Publication Title

Journal of Veterinary Anatomy

Publication Link

https://jva.journals.ekb.eg/

MainTitle

Effects of Organic and Inorganic Mercury on the Apoptosis of the Neural Tube Cells of Zebrafish Embryos (Danio rerio)

Details

Type

Article

Created At

22 Jan 2023