Objectives: This in-vitro study digitally evaluates the color matching ability of a single-shaded resin composite and a single-translucency resin composite system placed in teeth with three different shades at two different cavity depths, and to compare both of them to a multi-shaded resin composite system. Methods: 90 extracted sound teeth were selected and their shade was recorded. Teeth were divided according to their shade into three groups (S1,S2 and S3). In each group, Class V cavities were prepared at 0.5 mm depth (Subgroup D1) for half of the teeth, while cavities in the other half were adjusted at 1.5 mm depth (Subgroup D2). Each subgroup was further divided into three classes according to the restorative material placed in the prepared cavities (M1, M2 and M3). Shade was recorded after placement and ΔE was calculated. Results: Single-shaded resin composite (M1) recorded the significant lowest ΔE values wih S1 followed by S2 and S3 respectively (P ≤ 0.05). Multi-shaded resin composite (M3), generally showed the best results with the three teeth shades compared to the other two materials. No significant differences were found at both cavity depths for all groups (P ≤ 0.05). Conclusions: The single-shaded resin composite showed more acceptable color matching at lighter teeth shades than at darker teeth shades. Multi-shaded resin composite showed superior color matching ability at the three different teeth shades. The selected cavity depths had no siginificant effect on the color matching ability of the different resin composite materials used.