A field trial was carried out at the experimental farm in the El Qusiyah district, Assiut governorate, which  is  located  at 325 km south of Cairo, Egypt at latitude (27°29'2.58" N and longitude 30°39'3.23"E) during the winter growth season of (2019-2020) to investigate the impact of different doses (1, 2 and 3) of two compound fertilizers (19:19:19 and 15:5:5) with different application rates plus organic fertilizer (compost) at the rate (10 ton/feddan) (feddan = 4200 m² = 0.420 hectares = 1.037 acres) to assess their effects on some soil properties and wheat crop production. The results indicated that increasing of NPK nutrient by 78.06, 67.62 and 70.64% respectively above of control under treatment. Wheat crop treatment significantly increased weight of 1000 grain, straw yield, and grain yield by 45.92, 46.91 and 41.18% respectively in comparison to control. 19:19:19 treatment, at all tested doses, was the best agriculture practice that produces higher wheat yield as well as increased of available nutrient.