The objective of the current investigation was to assess the food deterrence property of chromafenozide and its impact on different food metabolic parameters of the 5^th instar nymphs of the desert locust Schistocerca gregaria. For this purpose, three doses (10, 100 and 150 µg/nymph) were topically applied (once) onto the newly molted last (5^th) instar nymphs. chromafenozide exhibited contradictory effects on the feeding since it acted as a weak antifeedant against female nymphs only at the lowest dose but acted as phagostimulant against their congeners at the higher two doses. Furthermore, the compound exerted a general phagostimulant action on the male nymphs, regardless the dose. The food intake by the last nymphal instar females was slightly reduced only at only the lowest dose but remarkably increased at the higher doses. The male nymphs had been promoted to consume more food amount. Treated nymphs of both sexes attained slightly or significantly increasing relative weight gain and discharged more frass pellets. The treated nymphs of both sexes achieved slightly increasing approximate digestibility (AD), with two exceptions for the male nymphs which had a slightly decreased AD at the medium dose and un-affected AD at the highest dose. Both the efficiency of conversion of ingested food into biomass (ECI) and efficiency of conversion of digested food into biomass (ECD) of the female nymphs slightly increased. ECI of male nymphs was enhanced but ECD was slightly inhibited. Depending on the present results, Chromafenozide cannot be recommended as a promising agent for controlling S. gregaria.