Two field experiments were conducted at a private farm in Malawi city, El-Minya, Egypt during two successive seasons of 2018 and 2019 respectively, to study the effect of organic, inorganic and its combination fertilizers on sweet potato yield and quality in a sandy clay loam soil, Treatments were (T1) 100% of inorganic fertilizer (NPK at mineral form), (T2) 100% organic fertilizer (sugarcane bagasse ash plus sugarcane vinasse), (T3) 75% organic fertilizer + 25% inorganic, (T4) 50% organic fertilizer + 50% inorganic, (T5) 25% organic fertilizer + 75% inorganic. A random complete block design (RCBD) with three replications was used. The data showed a high response to the full dose of organic fertilization treatments (5 ton /feddan of sugarcane bagasse ash plus 80 L /feddan of sugarcane vinasse (feddan = 4200 m² = 0.420 hectares = 1.037 acres)) at all vegetative growth and tuberous roots yield and quality. Meanwhile, the lowest values of sweet potato characters were obtained with full dose of inorganic fertilizers (NPK).