This research was conducted during the two consecutive seasons of 2017/2018 and 2018/2019 to study the effect of Filter mud as organic manure and biofertilizers application, as well as, their interaction on growth and some chemical  constituents of baldcypress (Taxodium distichum) seedlings. Filter mud was applied at 0, 24, 48, and 72 g/bag.  Biofertilizers were control, Active Yeast (AY), Minia Azotein (M.A.), Arbescular mycorrhizea fungi   (AM), AY+ M.A., AY+AM, M.A.+AM and AY+M.A.+AM. The most obtained results were as follows: The addition of filter mud at all levels led to a significant increase in plant growth traits (stem length, stem diameter, leaves fresh and dry weights /plant  and stem fresh and dry weights /plant, as well as, the elements of N, P and K % in the leaves), as compared to the check treatment. Utilizing the high level of filter mud (72 g/bag) registered the highest values of these parameters. In relation to biofertilizers treatments, all of them either separately or in combination, except for active yeast, in some cases, led to a significant augment in these previous traits. The application of triple inoculants (AY+ M.A. +AM) proved to be more effective in increasing these above mentioned parameters. In addition, for the interaction, it was significant effect on all examined characters, except for stem diameter. Clearly, most of combined treatments significantly increased all studied traits comparing to untreated ones. The most effective treatments were detected by using filter mud at the high level with the triple inoculants (AY+ M.A. +AM) in comparison with those obtained by other combination treatments.