Upconverting nanoparticles (UCNPs) have been of crucial significance in multiple applications involving photochemical, biomedical and optical ones. For the biomedical applications, one main problem that always stands as a challenge, hindering the upconversion scheme from being deployed inside human cells, is the challenging trade-offs among biomedical and field enhancement requirements imposed by the biomedical design constraints that deprive the UCNPs from field enhancement. Another challenge is imposed due to the constraint on the material choice that should achieve the required targeting, treatment/imaging, and electromagnetic design objective without any harm threatening the human body, which involves the dose limited by biodegradability and biocompatibility of the material. Although multiple field enhancement and manipulation techniques have been applied to UCNPs, there has never been a generic, material independent field enhancement method that could be invoked in biomedical applications without harming the human body despite achieving the required dose. This is a global transformation in the field of photoluminescence (PL) enhancement where there are constraints in the material, specially in biomedical applications, which has been the focus of this numerical and theoretical work. Besides, a more concrete explanation had to be provided to fit the practically obtained results that do not go in line with the conventional perception of electromagnetic waves guidance and confinement in nanostructures.