Liver transplantation was stated as the best solution for treating the end-stage liver disease patients but as there are some serious problems such as immune rejection, patients had to take immunosuppressive drugs for a long time after their transplantation process and this often leads to many dangerous side effects. So, an urgent alternative method was needed. Mesenchymal stem cell therapy (MSCT) after research become one of the very efficient methods to replace transplantation and its complicated consequences due to its immunomodulation property. This research mainly aims to show the effectiveness of Mesenchymal stem cell therapy (MSCT) through overviewing the current research and clinical trials which proved the safety of using the Mesenchymal stem cell therapy (MSCT) as alternative to transplantation with a high percentage. As a result, to the complications that might make someone lose his life or a vital part of his body, a new method in this paper would be identified to replace liver transplantation using python programming language and prop ability percentage to prove its essential need.