This research aimed at examining the direct impact of resonant leadership on strategic supremacy in foreign universities in Egypt and exploring whether attitudes toward organizational change play a mediating role in this relationship. The research began with a literature review resonant leadership, strategic supremacy and attitudes toward organizational change followed by developing a conceptual framework and formulating four main hypotheses. A field study was then conducted using a sample of 246 at three levels (top– middle- executive) at 8 foreign universities in Egypt and the number of completed questionnaires is 233. Collected data were analyzed using the Structural Equation Modeling. Statistical results revealed that all dimensions of the resonant leadership (Mindfulness, Hope and Compassion) have a statistically significant positive direct impact on strategic supremacy that can be measured by the following dimensions (sphere of influence, competitive configurations, Competitive compression) in 8 foreign universities in Egypt. Regarding the direct impact of resonant leadership dimensions on attitudes toward organizational change, it was found that all dimensions of resonant leadership have a statistically significant positive direct impact on attitudes toward organizational change. Moreover, Statistical results also revealed that attitudes toward organizational change have statistically significant direct impact on strategic supremacy. Finally, regarding the mediation of attitudes toward organizational change, findings showed that attitudes toward organizational change play a mediating role in the relationship between resonant leadership and strategic supremacy in foreign universities in Egypt.