The Inter-Carrier-Interference (ICI) and the Peak-to-Average-Power Ratio (PAPR) of the transmitted signal are considered as bottlenecks in the utilization of Multiple-Input-Multiple-Output Orthogonal Frequency Division Multiplexing (MIMO-OFDM) systems, which caused a significant performance degradation. In this paper Residue Numbers as a coding scheme is impeded in MIMO-OFDM systems, where the PAPR values are analysed and compared to non-RNS coding systems, and the ICI levels are measured and evaluated with respect to the conventional ICI mitigation techniques as pulse shaping, windowing and self-cancellation techniques implemented in MIMO-OFDM system. The ICI errors, Bit-Error-Rate (BER) and the Complementary Cumulative Distribution Function (CCDF) for MIMO-OFDM system with Residue Number System (RNS) coding are analysed and evaluated. The results demonstrated a performance enhancement of the transmission model over the system without RNS implementation.