This work presents a logic scheme for regulating the safe operation of research reactors in accordance with the IAEA Safety Series SS-35-S2 and revised by the Codes of Fedral Regulations 10 CFR. It emphasizes the regulatory inspection and enforcement (RI&E) program in the reactor operation licensing phases. It is developed to provide information ,
guidance and recommendations to be taken when constructing a RI&E program to be applied in the operational phase of the Egyptian research reactors. The RI&E procedures for regulating safe operation of research reactors are presented as flow charts, and then developed as a computer logic scheme. The software program is efficient , friendly, simple and interactive in nature such that the program asks the user certain questions about essential steps that guide the RI&E for research reactors and the user responds by (yes) or (no) and the program proceeds based on this response until all the necessary RI&E steps are accomplished. Samples of results of the RI&E software execution showing some violation cases with their inspective and corrective paths throughout the program are presented and discussed.