Multiprotocol Label Switching (MPLS) and Differentiated Services (DiffServ) play a vital role for minimizing the congestion by efficient load balancing and management of the network resources used to support Quality of Service (QoS). The lower network delay and efficient forwarding mechanism enhancing the speed of packet transfer make it more suitable for implementing real-time applications such as Voice and Video Conferencing. This paper evaluates the performance measures such as Packet Delay Variation (PDV) and end-to-end delay when applying some case studies comprising numbers of routers serving different number of clients. Both (PDV) and (End-to-End Delay) are determined using combination of Open Shortest Path First (OSPF), DiffServ and MPLS protocols. The results may lead to the measures of selection of the appropriate protocol.