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26645

INTERFERON ALPHA AND INTERFERON BETA GENES SEQUENCE DIVERSITY IN PAKISTANI BEETAL GOATS

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Last updated: 03 Jan 2025

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Abstract

Abstract Goat considered as an important member with unique biological component of livestock and an important economic resource around the world. Beetal goat is distinguish breed in Pakistan due to its superior production. The major histocompatibility complex (MHC) located on chromosome 23 of goat plays significant role in immune system. We sequenced the MHC Class I genes, interferon alpha and interferon β (IFN-α, IFN-β) in 35 samples of Beetal goat of Pakistan. In 361 bp fragment of IFN-α three mutations (A>G) were observed at position 83, 127 and 144 resulting in amino acid changes when compared with reference sequence accession No. XM005683621. The IFN-β was found more conserved as single non-synonymous mutation (G>C) that found at 258 position in 415 bp sequences of 40 animals comparing with reference sequence accession No. JX458085. This is the first report on MHC genes sequences in Beetal goat of Pakistan and the findings may lead to identification of molecular markers for selection of animals with better disease resistance.

DOI

10.21608/ejsgs.2015.26645

Authors

First Name

Tanveer

Last Name

Hussain

MiddleName

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Affiliation

Virtual University of Pakistan, Lahore.

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Orcid

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First Name

Atiya

Last Name

Yasmeen

MiddleName

-

Affiliation

Institute of Biochemistry and Biotechnology, University Veterinary Animal Sciences, Lahore, 54000.

Email

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City

-

Orcid

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First Name

Fiaz

Last Name

Hussain

MiddleName

-

Affiliation

Institute of Biochemistry and Biotechnology, University Veterinary Animal Sciences, Lahore, 54000.

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Orcid

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First Name

Abdulla

Last Name

Wajid

MiddleName

-

Affiliation

Institute of Biochemistry and Biotechnology, University Veterinary Animal Sciences, Lahore, 54000.

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City

-

Orcid

-

First Name

Asif

Last Name

Nadeem

MiddleName

-

Affiliation

Institute of Biochemistry and Biotechnology, University Veterinary Animal Sciences, Lahore, 54000.

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Orcid

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First Name

Maryam

Last Name

Javed

MiddleName

-

Affiliation

Institute of Biochemistry and Biotechnology, University Veterinary Animal Sciences, Lahore, 54000.

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City

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Orcid

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First Name

Tahir

Last Name

Yaqub

MiddleName

-

Affiliation

Institute of Biochemistry and Biotechnology, University Veterinary Animal Sciences, Lahore, 54000.

Email

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City

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Orcid

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First Name

Ali

Last Name

Sheikh

MiddleName

Ahmad

Affiliation

University Diagnostic Lab, University of Veterinary and Animal Sciences, Lahore, 54000.

Email

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City

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Orcid

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First Name

Masroor

Last Name

Babar

MiddleName

Ellahi

Affiliation

Virtual University of Pakistan, Lahore.

Email

-

City

-

Orcid

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Volume

10

Article Issue

2

Related Issue

4771

Issue Date

2015-08-01

Receive Date

2019-02-06

Publish Date

2015-08-01

Page Start

1

Page End

1

Print ISSN

2090-0386

Online ISSN

2090-0376

Article File

EJSGS_Volume 10_Issue 2_Pages 1-1.pdf

PDF . 127.6kB

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https://ejsgs.journals.ekb.eg/article_26645.html

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https://ejsgs.journals.ekb.eg/service?article_code=26645

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6

Type

Original Article

Type Code

728

Publication Type

Journal

Publication Title

Egyptian Journal of Sheep and Goats Sciences

Publication Link

https://ejsgs.journals.ekb.eg/

MainTitle

INTERFERON ALPHA AND INTERFERON BETA GENES SEQUENCE DIVERSITY IN PAKISTANI BEETAL GOATS

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Type

Article

Created At

22 Jan 2023