Background:  Chronic lymphocytic leukemia ,most common leukemia in western countries ,is characterized by accumulation of mature CD19,CD5,CD23 positive B cells. Indeed, microenvironments in the bone marrow, lymph node and other secondary lymphoid organs have been shown to inhibit spontaneous CLL cell apoptosis and enhance chemoresistance. Aim of the work: To study the clinical utility of CD184 in CLL patients,so that it can be used as routine investigation to predict the outcome of the disease and to help in choosing treatment regimen.
Patients and methods: 33  newly diagnosed CLL patients at Nasser institute and Ainshams university hospitals, have undergone  CBC , LFt, KFT; Virology, LDH,B2microglobulin, bone marrow aspiration and biobsy, immunophenotyping , cytogenetics, radiological investigation, And CD184  by flowcytometry which has been correlated with these diagnostic and prognostic parameters.
Results:  Positive correlation was found between CD184 and TLC, Lymphocytic count ,LDH,B2microglobulin,RAI stage and revised RAI score, while negative correlation was found between CD184  and both HB and platelet count.
Conclusion: High CD184 expression associated with poor prognosis of CLL patients,so that it can be used as routine investigation to predict outcome of disease/