Brain Natriuretic Peptide (BNP) and electrolytes are important biomarker in myocardial infraction. To evaluate the relationship between Electrolyte (Sodium, Potassium, Chloride), BNP, Nitric Oxide, and Immunoglobulin in patients with myocardial infarction (MI), 25 patients with heart failure and 10 clinically healthy subjects (control), were used. The results of the present study showed the association between BNP and electrolytes, nitric oxide in addition to immunoglobulin. The results showed a decrease in sodium, potassium, chloride, and immunoglobulin except IgE and increase in BNP and NO. These parameters may be regarded as predictors or risk factors of MI.