The use of medicinal plants as a dietary supplement is increasing in parallel with the research on it's therapeutically roles on human health. A literature survey indicated that polyphenols from Jasonia montana represent a promising antioxidant activity. Quercetin is the most common Jasonia montana polyphenols. Also, Jasonia montana quercetin derivatives act as antioxidants in vitro by scavenging reactive oxygen and nitrogen species and chelating redox-active transition metal ions. This review will discuss the mechanism of antioxidant and chelating activity of quercetin in an attempt to understand its mechanism of action, which may pave the way for possible therapeutic applications.