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30310

Comparison of Biochemical effects of glibenclamide and some trace elements on experimental diabetic rats

Article

Last updated: 03 Jan 2025

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-

Tags

Medicine

Abstract

The present work was done to elucidate the possible protective and antidiabetic effect of chromium chloride (Cr) (500 mg/k.g.), sodium selenite (Se) (1.5 mg/k.g.) and Zinc sulphate (Zn) (54 mg/k.g.) supplementation in streptozotocin induced diabetic rats. Oral administration of both Cr+3 and Zn+2 as well as intraperitoneal injection of Se-2 at concentrations of 500, 1.5 and 54 mg/kg b.w. daily, respectively for 60 days showed a significant decrease in fasting blood. The treatment also resulted in a significant increase in plasma C-peptide and trace elements Cr+3 and Zn+2 and Se-2. The trace elements exerted rapid protective effects against lipid peroxidation by scavenging of free radicals  by reducing the risk of diabetic complications. 

DOI

10.21608/sjou.2018.30310

Keywords

glucose, diabetic rats, Cr+3 and Zn+2 and Se-2, C-peptide

Authors

First Name

Suzan

Last Name

Shawky

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Applied Medical Sciences, October 6 University, Egypt

Email

-

City

-

Orcid

-

First Name

Samy

Last Name

Abdel-Aziz

MiddleName

A

Affiliation

Department of Biochemistry and Nutrition, Faculty of Veterinary Medicine, Cairo University, Egypt

Email

-

City

-

Orcid

-

First Name

Hassan

Last Name

Amer

MiddleName

A.

Affiliation

Department of Biochemistry and Nutrition, Faculty of Veterinary Medicine, Cairo University, Egypt

Email

-

City

-

Orcid

-

First Name

Ismail

Last Name

Hegazy

MiddleName

I.

Affiliation

Department of Biochemistry, Faculty of Applied Medical Sciences, October 6 University, Egypt

Email

-

City

-

Orcid

-

First Name

Mohammed

Last Name

Hussein

MiddleName

A

Affiliation

Department of Biochemistry, Faculty of Applied Medical Sciences, October 6 University, Egypt

Email

prof.husseinma@o6u.edu.eg

City

-

Orcid

-

Volume

4

Article Issue

2

Related Issue

5250

Issue Date

2018-01-01

Receive Date

2018-03-10

Publish Date

2018-01-01

Page Start

1

Page End

7

Print ISSN

2314-8640

Online ISSN

2356-8119

Article File

SJOU_Volume 4_Issue 2_Pages 1-7.pdf

PDF . 366.4kB

Link

https://sjou.journals.ekb.eg/article_30310.html

Detail API

https://sjou.journals.ekb.eg/service?article_code=30310

Order

1

Type

Original Article

Type Code

724

Publication Type

Journal

Publication Title

Scientific Journal of October 6 University

Publication Link

https://sjou.journals.ekb.eg/

MainTitle

Comparison of Biochemical effects of glibenclamide and some trace elements on experimental diabetic rats

Details

Type

Article

Created At

22 Jan 2023