: In the last 20 years, laparoscopic surgery has advanced at a remarkable pace. The standard for the management of hematologic diseases of the spleen is laparoscopic splenectomy (LS). Aim and objectives: The goal of the research was to evaluate laparoscopic and open splenectomy patients in terms of operating time, intraoperative complications, hospitalization length, and duration to return to normal activities. Subjects and methods: Twenty patients with hematological and benign splenic disorders were included in prospective research at Al-Azhar University Hospitals (Al-Hussein and Sayed Galal). They were divided into groups at random by picking every two patients and assigning one to group (A) and the other to group (B), with each group consisting of ten patients. Group (A) undergo laparoscopic splenectomy. Group (B) undergo open splenectomy. Results: There is significant reduction in the hospital stay between both group (P=0.00). Patients in lap group were dismissed from the hospital on the 2nd postoperative day (8cases), but (2cases) were discharged on the 3rd day as they were converted to open surgery with median stay in hospital 1.3 days. Conclusion: LS are efficient in producing the desired therapeutic response in patients with suitable indication for splenectomy. The operative times for Laparoscopic splenectomy are longer than those for OS but they tend to decrease with experience. The intraoperative blood loss and complications of LS are generally better than those reported for OS.