Background: Ductus venosus doppler has effective role in treatment of disorders that put the fetus at risk of cardiovascular diseases. In antenatal assessment, Doppler ultrasonography is increasingly being used to evaluate the blood flow volume rate in vessels during the cardiac cycle in the fetoplacental, uteroplacental circulation. Aim of the work: To discover if ductus venosus Doppler velocimetry may give earlier prediction of fetal hypoxemia than umbilical and middle cerebral artery blood doppler velocity in high-risk pregnancy or not. Patients and methods: According to the inclusion criteria, 60 pregnant women after the age of fetal viability (28 weeks of pregnancy) were included in the study. In order to facilitate statistical description, we divided the cases into 2 groups (Hypoxic and Non-Hypoxic groups), according to Apgar score, if less than 7 at 5 minutes or Cord PH less than 7.35. Results: The best cut-off value for the ductus venosus RI was >0.45 with a sensitivity of 98.7%, specificity of 56.7%, positive predictive value (PPV) of 80%, and negative predictive value (NPV) of 100%. When comparing the diagnostic ability of ductus venosus RI and middle cerebral artery systolic/diastolic ratio, the ductus venosus resistance index showed the highest diagnostic ability 91% against 71% for the middle cerebral artery systolic/diastolic ratio. Conclusion: Ductus venosus Doppler US is a useful way to assess fetoplacental circulation and has a good ability to predict fetal low oxygen. The most reliable index to predict low oxygen is the resistance index.