Background: Primary postpartum hemorrhage (PPH) is among of the most main sources of mother deaths throughout the world. The changed profile of laboring women, who are now more probable to be aged, overweighted, or have substantial clinical co-morbidities, is leading to an increase in obstetric difficulties, Aim and objectives: in a double-blind controlled experiment, to examine the impact of an intramuscular (IM) single dose of oxytocin (10 IU per 1 mL) and placebo IV administration (1 mL 0.9 % saline gradually administered ) with an IV single dose of oxytocin (10 IU per 1 mL administered gradually over 1 min) and placebo IM administration (1 mL 0.9 % saline) during natural birth, Subjects and methods: The randomized controlled experiment was carried out at Al Azhar University's EL Hosain Hospital. It featured 200 ladies who wanted to give birth vaginally, Result: severe postpartum hemorrhage and blood transfusion were significantly more frequent in intramuscular group compared to intravenous group, Conclusion: In comparison to intramuscular oxytocin, intravenous oxytocin causes less severe PPH, blood transfusions, and induction to a critical care unit at the third phase of labor, and has fewer adverse effects.