Background: The main cause of maternal morbidity and mortality, intrauterine growth retardation, as well as fetal prematurity, is pre-eclampsia. Helicobacter pylori was found to infect several parts of the stomach and duodenum and has consequently been linked to a higher risk of gastric cancer. Pre-eclampsia is more frequent in women infected with H. pylori than in women who are not. Aim of the work: To assess the relation between severity of pre-eclampsia and of Helicobacter pylori infection. Patients and methods: This case-control research involved 100 pregnant women at the Obstetrics and Gynecology Departments of Al-Azhar Hospital and Mansoura International Hospital, with 50 healthy, normal pregnant women in group A (the control group) and 50 cases diagnosed with pre-eclampsia in group B (the case group). All participants underwent the taking of history, a complete general examination, an obstetric examination, and laboratory investigations. A serological diagnosis of H. pylori infection has been made utilizing anti-H. Pylori IgG detection. Results: In the preeclampsia group, H. pylori was statistically significantly higher. The frequency of IUGR, maternal ICU admission, and neonatal ICU admission among the preeclampsia group has increased statistically significantly. There have been statistically significant positive connections across HP positivity and elevation in SBP/DBP as well as the degree of proteinuria among the pre-eclampsia group. There has been a statistically significant increase in IUGR incidence and maternal ICU admission among pre-eclampsia cases who tested positive for HP infection. Conclusion: Study suggess that HP infection impairs the process of placentation and thus is a risk factor for PE incidence.