Background: Burn injury management requires a lot of time and resources. Most patients need lengthy hospital stays. Aim of the study: To determine the impact of manufactured fat emulsion on protein loss in burn patients. Patients and Methods: This Randomized controlled study included 20 patients of 20% up to 40% of TBSA that were hospitalized to department of plastic and reconstructive surgery, Al-Azhar University hospital, which was prospectively be simple into two groups. Group (A) were subjected manufactured fat emulsion IV infusion. Group (B) controlled. The study duration ranged from 6-12 months. The patient administrates 1-1.5g /per kg of intralipid (20%) from post burn day 4. venous blood samples were taken for testing total protein, albumin, total cholesterol and triglyceride and 24 hours' urinary creatinine on post burn days 1st, 7th ,14th, 21st, 30th respectively. Result: There is a substantial reduction in total protein, plasma albumin and urinary creatinine from 1st day to 21days among group A and group B. However, there is a slight change in cholesterol and triglycerides without statistically significant difference. at 1st day and 7th day, total protein, plasma albumin, cholesterol and triglycerides were comparable in both groups without statistically significant difference. At 14th day total protein was substantially greater in group A compared to group B. At 21st and 30th day total protein, plasma albumin was significant higher in group A compared to group B. Conclusion: The intralipid 20 percent IV infusion is a useful energy source to reduce albumin loss in severely burnt individuals.