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270891

The Additive Effect of Topical Dorzolamide-Timolol with Intravitreal Ranibizumab Injection in Diabetic Macular Edema

Article

Last updated: 22 Jan 2023

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Abstract

Background: Diabetic macular edema (DME) is a main reason for vision affection when occurred at any stage of diabetic retinopathy. Anti-vascular endothelial growth factor agents is the gold standard treatment for DME. Adjuvant agents may decrease edema and improve vision. Aim of the work: To assess influence of topical dorzolamide–timolol with intravitreal ranibizumab injection (IVR) on anatomical and functional outcomes in DME. Patients & Methods: This prospective cohort study included thirty patients (30 eyes) having type 2 DM, aged 45-60 years, all eyes have DME. They were divided into 2 groups according to treatment protocol: Group 1: 15 patients (15 eyes) received IVR (3 monthly injection of Lucentis® 0.5 mg/0.05 ml) and adjuvant topical dorzolamide-timolol (Xolamol™ eye drops twice daily). Group 2: 15 patients (15 eyes) received IVR only. Results: Mean BCVA variations were significant in both groups, it varied from 0.93 ± 0.23 logMAR at baseline to 0.73 ± 0.27 (P < 0.001) in group 1 & from 0.93 ± 0.3 logMAR to 0.8 ± 0.33 (P = 0.001) in group 2. Variations in mean CMT were significant in both groups, it varied from 568.67 ± 145.76 at baseline to 384 ± 110.63 (P ˂ 0.001) in group 1 & from 513.4 ± 114.54 at baseline to 387.87 ± 119.52 (P ˂ 0.001) in group 2, at 4th month. Conclusion: This study demonstrated that adjuvant topical dorzolamide -timolol with IVR included additional effects, but not a statistically significant, on IVR in treatment of DME over 4-month- course.

DOI

10.21608/aimj.2022.166168.2216

Keywords

Diabetic Macular Edema, Dorzolamide-Timolol, Intravitreal Ranibizumab

Authors

First Name

Sara

Last Name

Gadwal

MiddleName

Mohamed

Affiliation

Ophthalmology resident at Al-Mataria Teaching Hospital (Cairo, Egypt)

Email

saragadwal91@gmail.com

City

samanoud

Orcid

-

First Name

Wafaa

Last Name

Madbouly

MiddleName

Ahmed

Affiliation

Professor of Ophthalmology, Faculty of Medicine (for Girls), Al-Azhar University, Egypt,

Email

wafaamadbouly57@gmail.com

City

-

Orcid

-

First Name

Mona

Last Name

Mansour

MiddleName

Nabeh

Affiliation

3 Assistant Professor of Ophthalmology Department, Faculty of Medicine (for Girls), Al-Azhar University, Egypt

Email

mmansour04@azhar.edu.eg

City

-

Orcid

-

Volume

3

Article Issue

11

Related Issue

37897

Issue Date

2022-11-01

Receive Date

2022-10-03

Publish Date

2022-11-01

Page Start

191

Page End

196

Print ISSN

2682-3381

Online ISSN

2682-339X

Link

https://aimj.journals.ekb.eg/article_270891.html

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https://aimj.journals.ekb.eg/service?article_code=270891

Order

31

Type

Original Article

Type Code

710

Publication Type

Journal

Publication Title

Al-Azhar International Medical Journal

Publication Link

https://aimj.journals.ekb.eg/

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Article

Created At

22 Jan 2023