Background: Adult stroke, particularly cardioembolic stroke, is a prominent consequence of mortality and illness, but the cause is frequently unknown. Aim and objectives; to study role of left atrial dysfunction as an etiological factor in ischemic stroke using 2D speckle tracking echocardiography. Subjects and methods: The Al-Hussein Hospital Al-Azhar University hosted this prospective cohort study. The TOAST classification was used in this study, which included 40 patients with ischemic stroke. Result: The ECHO- LAD in the study population ranged from 2.1 to 5.3 with mean ± SD = 3.11 ± 0.86. The ECHO- AO in the study population ranged from 2 to 5.1 with mean ± SD = 3.41 ± 0.71. The ECHO- LVEDd in the study population ranged from 4 to 5.9 with mean ± SD = 4.89 ± 0.51. The ECHO- LVESd in the study population ranged from 2 to 5.2 with mean ± SD = 3.46 ± 0.71. The ECHO- EF in the study population ranged from 37 to 77 with mean ± SD = 56.15 ± 9.96. The ECHO- FS in the study population ranged from 18 to 44 with mean ± SD = 32.2 ± 8.45. Conclusion: 2D-STE is a quick and dependable approach for assessing dynamic LA functions in patients with ischemic stroke. Hypertension , diabetes, carotid artery stenosis and atrial Fibrillation were potential risk factors for ischemic stroke.