Background - Recurrent pregnancy loss (RPL) refers to the occurrence of two or more consecutive losses of clinically recognized pregnancies prior to the 20th week of gestation (ectopic, molar, and biochemical pregnancies are not included). It may be primary or secondary. 0.4 to 1 percent of women have three consecutive pregnancy losses.
Aim - to evaluate the Doppler parameters (Resistance Index and Pulsatility index) in the uterine arteries of non-pregnant women with recurrent miscarriage.
Patients and Methods - This study conducted on 40 non pregnant women complaining of unexplained recurrent pregnancy loss, from those patients attending gynecology clinic of Al –Azhar university outpatient clinic in Assuit. Patients were classified into: IMN group: (20 patient) complaining of unexplained RPL receiving isosorbide mononitrate vaginally (IMN) 20 mg tablet Placebo group: (20 patient) complaining of unexplained RPL receiving placebo.
Results - Our results revealed that S/D ratio and pulsatility index (PI) and resistance index (RI) of the uterine artery had fallen in IMN group with no significance difference in placebo group.
Conclusion - As per our result observed that Isosorbide mononitrate as a nitric oxide donor can be improved Doppler indices, so may be an important drug in treatment of cases of unexplained RPL.