Background: Neuroendoscopic procedures have shown great success as being minimally invasive surgery, which can deal with a lot of intra- and peri-ventricular pathologies. (1) Herein we were to describe the precise topographical relations of specific lesions to individual anatomic variations of intraventricular structures. Aim of the study: studying the accessibility and maneuverability of each recorded anatomical target through visualization and interpretation of neuroendoscopic video-captured images. Patients and methods: Consecutive surgical series of one-year duration conducted at Al-Azhar University Hospitals. Out of our series which reached 64 endoscopic cases, we selected cases that showed interesting anatomical variations. In our research, we included 13 Patients who are candidates for neuroendoscopic surgeries of ages ranging from 6 months to 39 years and fulfilled our criteria. Herein, in this paper, we included a sample of 2 cases. Results: Images description and labeling of important anatomical structures around the 3rd ventricle. Besides, we were able to analyze variable anatomy of the floor of the 3rd ventricle & Liljenquist membrane that increase the surgical challenge and affect the outcome. Conclusion: Our study was able to participate in achieving safer surgical freedom through understanding the critical landmarks, besides, studying the accessibility and maneuverability of each target. It can help novice neurosurgeons to be ready and well prepared for several surgical challenges based on better anatomical understanding, necessary instrumentation, and skills.