Background: The use of endoscopic endonasal trans-sphenoid surgery (EETS) as the first-line therapy for most pituitary adenomas is gaining popularity. Aim and objectives: The primary goal of this research was to see how an transsphenoidal endoscopic technique for a growth hormone-secreting pituitary adenoma affected hormonal reduction in relation to surgical excision extent. Subjects and methods: This prospective research was carried out at the Al Azhar University Hospitals' neurosurgery department (Al Hussien and Sayed Galal).This study was conducted on 15 cases with Growth hormone secreting pituitary adenoma that had undergone total or subtotal resection performed by endoscopic endonasal transsphenoidal surgery. Results: there was highly statistically substantial (p-value < 0.001) decreased post-operative growth hormone (3.4 ± 1.2) when compared with pre-operative growth hormone (38.1 ± 29.8). Highly statistically significant (p-value < 0.001) decreased post-operative IGF-1 (242.3 ± 102.1) when compared with pre-operative IGF-1 (665 ± 253). No statistically significant difference (p-value > 0.05) between pre-operative and post-operative the following hormones (ACTH, cortisol, T3, T4, TSH, testosterone, FSH, LH and PRL, estradiol). Conclusion: In individuals with acromegaly, the endoscopic endonasal transsphenoidal technique is an efficacious and secure treatment for adenomas. We discovered that using an endoscopic endonasal transsphenoidal technique reduced growth hormone and insulin-like growth factor-1 levels considerably.