ABSTRACT
Background: Mortality from Covid-19 is higher among patients with chronic diseases.
Aim of The study : evaluate predictors of severe illness in patients' coronavirus diseases.
Patients and Methods: retrospective study included 200 patients with COVID 19 pneumonia admitted in chest departments, Patients divided into 2 groups; Group1had 100 patients (30 male patients and 70 female) had pneumonia manifestations on radiology and had risk factors, group 2 was a control group 100 patients (53 male patients and 47 female) had pneumonia manifestations on radiology and hadn't risk factors. Mild Covid 19cases with lymphopenia or leucopenia without radiological signs of pneumonia and Pediatric cases of Covid 19 excluded. Detailed history, clinical examination, Identifying coronavirus by transcription-polymerase chain reaction, arterial blood gases, complete blood picture, Liver functions testes, blood urea and serum creatinine, (CRP), D-dimer serum ferritin, CT chest.
Results: most common comorbid conditions were systemic hypertension (62%), diabetes mellitus (61%), and ischemic heart disease (48%)). older age and SpO2 <74% were significant predictors for invasive respiratory support or in-hospital death, patients with risk factors had myalgia (22%), chest pain and DCL symptoms 11%. D-dimer identified as an independent risk factor (P value 0.034), serum creatinine in Group 1 is higher than group2.
Conclusion: Advanced age was more liable for infection with COVID-19. Hypertension, diabetes mellitus and ischemic heart disease were independently associated with a higher risk of in-hospital death. COVID-19 infected patients with risk factors had poor outcome. Chronic patients had Lower blood oxygen saturation.