Abstract
Background: Diabetes is a metabolic condition with a variety of consequences that can lead to serious sickness in the long run. The disease has severe economic consequences and, sadly, is rapidly approaching a pandemic threshold over the globe. To overcome this disorder and associated pathogeneses, much research is now being conducted.

Methods: Outpatient volunteers with type II diabetes and their first or second-degree relatives served as controls. Between January and August 2021, All individuals had a history and physical examination, which included a body mass index (BMI), blood samples for 8-hour fasting blood sugar, 2-hour postprandial blood sugar, and liver and kidney function tests (ALT, AST, Urea, Fasting Serum Insulin.).
Insulin Resistance Assessment Using a Homeostasis Model (HOMA-IR).

Results: The relationship between ceramides and insulin resistance indicators was investigated using correlation analysis and linear regression models. Ceramides with shorter (C16:0, C18:0) and longer chains (C24:1, C30:10) had a moderate to substantial connection with HBA1C and HOMA-IR, respectively (Table 2). Only long-chain polyunsaturated ceramides (C26:9) had a significant favorable influence on HBA1C and HOMA-IR in the regression model (Estimate: 1.7, P 0.001) and (Estimate: 8.9, P 0.001).
Ceramides with shorter and longer chains are moderately linked to insulin resistance. Long-chain polyunsaturated ceramides were also found to have the strongest link to HBA1C and HOMA-IR. Advances in our understanding of these interactions open up new possibilities for creating diabetes and insulin resistance treatment targets and biomarkers.