Background: Sepsis continues to be a major cause of death and high healthcare expenses around world. prevalence and fatality rate related to sepsis continue to rise. In management of sepsis, time is of the essence; recent studies have shown that early and intensive therapy is critical for lowering mortality. In 30–50% of cases, sepsis therapy begins in emergency department.
Objective: To detect efficacy of serial serum lactate and lactate clearance in comparison with APACHE Il as a prediction of fatality in septic patients within 28 days following initial resuscitation and within first 24 hours in intensive care unit.
Patients and methods: This study was started from January to December 2021. It has been conducted on 53 adult patients (n = 53) who have been brought to Critical Care Unit with a diagnosis of sepsis as defined by current guidelines and who met inclusion criteria, but 3 patients excluded. One was developed gastrointestinal bleeding, 2nd patient was due to myocardial infraction, last one excluded due to data collection error, so we carried study on 50 patients (n=50).
Results: APACHE II shows a significant increase in non-survive group. Arterial lactate shows a highly significant increase in non-survive group, lactate clearance shows a significant decrease in non-survive group < br /> Conclusion: Serum lactate level and lactate clearance as an indicator of shock and resuscitation are more reliable predictors of mortality than APACHE II. if resuscitation decreased lactate clearance to normal levels in 12 to 24 hours, the patient has best chance of survival