Background; The Textile production industry is one of the most precious technologically complex of all industries because of the variety of substrates, processes, machinery, and components used and finishing steps undertaken.

Aim and objectives: was to compare the effect of maternal exposure to natural fibers and synthetic fibers used in the textiles industry among women textile workers, on pregnancy outcomes, at Misr Spinning and Weaving Company in El Mahalla El Kubra and Tanta, Egypt.

Subjects and methods: The study deals with, a comparison between the effect of maternal exposure to natural fibers and synthetic fibers used in textiles industry on pregnancy outcomes conducted in Corporation with the Egyptian Ministry of Health, at Textile factories in Al-Mahalah Al-Kubra and Tanta, during the period from February 2021 to February 2022.

Result: No significant differences in mean intra-pregnancy BMI, and age between exposed and control groups. Mean duration of exposure to textile pollution in the exposed group was (8.3±0.6) years; (20 %) exposed between 2 and 6 years; (44 %) exposed between 6 and 10 years and (36%) exposed more than 10 years. Conclusion: Pregnant women exposed to textile induced pollutions inside Misr Spinning and Weaving Company. at increased risk of the adverse pregnancy outcomes with a particular TLBW, preterm birth, miscarriage hypertension, and congenital anomalies. There was significant statistical difference between natural and synthetic fibers. It was also noticed that there was marked improvement in maternal outcome in group exposed to natural fibers in comparison to synthetic fibers group.