Background: Parkinson's disease (PD) is an incurable multisystem condition that causes enormous morbidity and costs in healthcare. The most frequent non-motor symptoms (NMS) manifestations of PD are gastrointestinal (GI) dysfunctions, which affect roughly 65% of people.
Aim of the Work: To define the frequency of GI symptoms in PD (both treated and untreated), and to correlate the existence or lack of GI symptoms with stages of the disease.
Subjects and Methods: From February 2021 to August 2021, this case research was carried out in tertiary care at Al-Azhar University Hospitals Al-Hussein and Sayed Galal on a total of 120 subjects, divided into 60 Parkinson's disease patients and a matching group of healthy individuals.
Results: This study showed that upper gastrointestinal tract dysfunction, which has been evaluated by the Leeds dyspepsia questionnaire, and lower gastrointestinal tract dysfunction, which was assessed by the Cleveland Constipation Score and Rome-IV criteria, had a highly significant difference between PD and the healthy control group.
Conclusion: The most common gastrointestinal premotor symptoms of Parkinson's disease were constipation and defecatory dysfunctions.