Background; in a genetically predisposed host, ulcerative colitis (UC) is a kind of Chronic idiopathic inflammatory bowel disease (IBD), marked by an unregulated immune response produced by the gut microbiota.
Aim and objectives; to determine the level of serum amyloid A as a novel predictor of ulcerative colitis disease activity
Subjects and methods; this is a prospective study that will take place at Al-Azhar University Hospitals (Al-Hussein and Bab-Elsheria). Patients were categorized into three groups: Group I: twenty-five patients confirmed with ulcerative colitis during remission state. Group II: twenty-five patients confirmed with ulcerative colitis during exacerbation state (activity state). Group III: Included twenty-five healthy volunteers. Serum amyloid A measurement done during remission and activity.
Results; High sensitive predictive value of Serum amyloid A level was in mild diseases, and the most specific predictive value was in severe diseases. Moderate ulcerative colitis was the most common in the active ulcerative colitis group.
Conclusion; For UC diagnosis and management, the level of SAA in the blood can be used as a potentially accurate laboratory biomarker, as well as disease activity and prognosis assessment.