Background: Angiopoietin-like protein 4 (ANGPTL4) is a glycoprotein that regulates LPL activity during fasting and thereby affects triglyceride metabolism. In the nephrotic syndrome, ANGPTL4 has been proposed as a relationship between hypertriglyceridemia and albuminuria. In this study, the levels of circulating ANGPTL4 in individuals having diabetic nephropathy (DN) were investigated, as well as their relationship with confirmed DN.
Aim of the work : In this study, we wanted to explore a potential role of ANGPTL4 under conditions of T2D alone and DN, where a changes in ANGPTL4 levels would be permissive for the development of a kidney condition as a complication of diabetes. This would promote the use of ANGPTL4 as a biochemical marker for the detection of nephropathy in patients with diabetes
Objective: Measurement of ANGPTL4 level in patients having T2D but without DN. Patients with T2D and DN, as well as healthy people, will be evaluated to determine its potential role in management.
Subjects and methods: This study included 60 patients. 20 patients who had T2D but no DN (T2D group I) 20 patients who had T2D and DN (DN group II) 20 individuals without T2D and no nephropathy (control group). We assessed serum ANGPTL4 levels in all groups via an enzyme-linked immunosorbent assay (ELISA).

Results: In our study, patients with T2D with DN had significantly greater ANGPTL4 levels than patients with T2D without DN and control subjects (healthy group). HBA1c showed a positive correlation.

Conclusion: Use of ANGPTL4 as a Predictive Marker for DN in T2D.