Background: Warts are benign skin lesions that occur as a result of infection with human papillomavirus (HPV). Warts are classified according to their sites and shapes as (i) Common wart; (ii) Plantar wart; (iii) Plane wart and (iv) Genital wart (condyloma accuminatum). The type of wart present on the plantar surface of the foot is called planter wart and there are various types of HPV have been identified to cause planter warts including HPV-1, -2, -3, -4, -27, -29, -57, -60, -63, -65, -66, and -69. It has been already established that radical treatment of warts is often challenging for both the physician and the patient.
Objective: To assess the effectiveness of Intralesional Methotrexate in comparison with 5-Flurouracil in treatment of Plantar Warts.
Patients and methods: The study was carried out on 40 patients with planter warts. Two groups of patients were obtained. Group A included 20 patients were injected MTX in full concentration into the base of the wart and Group (B) included 20 patients were injected intralesional 5 Fluorouracil in full concentration.
Results: There is a significant difference between the two groups as regard the response (Group B -5-FU group- is more effective) with no statistical significant difference between the 2 groups as regard the type, number, duration of warts or the complications of injection.
Conclusion: MTX is less effective than 5-FU in treating plantar warts.