Background: Omega-3 improves fetal wellbeing. New results suggest that maternal docosahexaenoic acid supplements can help to normalize adipose malfunction and enhance adiponectin-induced enhancements in metabolism functioning in fetuses with intrauterine growth restriction
Objectives: Our study is the first RCT, to our knowledge, using the combination of omega-3 fatty acid and aspirin in the therapy of IUGR.
Subjects and Methods: The research compared the effects of low dosage aspirin and low molecular weight heparin and low dosage aspirin and low molecular weight heparin with omega-3 on asymmetrical IUGR fetuses in a certified, single-center, open-randomized, parallel treatment clinical trial. At the Obstetrics and Gynecology Department of Al- Hussein University Hospital and the Obstetrics and Gynecology Department of Bolak Eldakror General Hospital in Giza, Egypt, 100 women who are pregnant (28–32 weeks) with IUGR participated in this study.
Results: The flow of blood in uterine arteries after treatment was significantly different in all parameters and S\D before treatment for patients using aspirin + low molecular weight heparin than for women managed with aspirin + low molecular weight heparin plus omega3 fatty acid, the distribution of blood flow in uterine arteries shows no any statistically significant before treatment in (RI and PI) in the case of after treatment and S\D before treatment shows highly statistically significant.
Conclusion: The combination of aspirin and omega-3 fatty acid is an efficient therapy for asymmetrical IUGR. Study of the extended impact of omega-3 fatty acids on women with asymmetrical IUGR.