Background: lumbosacral spondylolisthesis is a common pathology characterized by single or multi-level slippage of lumbar vertebra over the other and may be associated with spinal canal stenosis and neural foramina compromization and may be presented by lower back pain, radicular pain, or neurogenic claudication pain. The current study aimed to compare the short-term clinical outcomes of two surgical fusion techniques in the management of this pathology.Aim of the work: Comparative study to evaluate outcome clinically and radiologically in cases of 1st and 2nd grade of degenerative lumbar spondylolisthesis treated with transpedicular fixation with or without interbodyfusionbylumbar cage. Patients and Methods: 40 patients of lumbosacral spondylolisthesis were included in this study. Patients randomly divided into two groups according to the surgical approach and fixation technique used in the management. Group (A): operated by posterior lumbar decompression, transpedicular screw fixation and posterolateralintertransverse bony fusion. Group (B): operated by posterior decompression, transpedicularscrew,posterolateralinterbony fusion by insertion of interbody cages. Results: Statistical significance was reached in blood loss, and post-operative fusion rates, but there was no significant difference between the two groups regarding to intra-operative or post-operative complication rates, clinical outcome and patient satisfaction.Conclusion: The application of the lumbar interbody cage with posteriorlateralintertransverse fusion proved to have better fusion rates, but still intertransverse bony fusion alone gives the same results regarding patient satisfaction and post-operative clinical improvement with shorter operative time.