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Evaluation Of Intralesional Injection Of Botulinum Toxin Type A, Methotrexate, And Verapamil In Treatment Of Keloids: A Preliminary Study

Article

Last updated: 03 Jan 2025

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Abstract

Abstract

Background: Keloids are due to overgrowth of dermal collagen following trauma to the skin that usually cause major physical, psychological and cosmetic problems. Intralesional injection treatments show promising results and many agents have been used as single treatments or in combination to get the best result.
Patients and Methods: This is a prospective comparative non-randomized clinical study including 20 patients with 30 keloid lesions divided into 3 groups A, B and C including 10 lesions each. Group A received intralesional injection of Botulinum toxin Type A (BTX-A) 2 U/cm2, Group B was treated with Methotrexate (MTX) 1 mg/cm2 and group C with Verapamil 0.125 mg/cm2.
Results: The percentage of improvement of VSS was better in group A than group C which was statistically significant (p2=0.01). Also, group B was better than group C in the percentage of improvement of VSS which was statistically significant (p3<0.01), while, there was no statistically significant difference in the percentage of improvement between group A and group B (p1=0.233).
Conclusion: our study supports the efficacy of the 3 mentioned drugs in treatment of keloids with better results obtained from intralesional injection of Botulinum Toxin A and Methotrexate than Verapamil.

DOI

10.21608/aimj.2022.106057.1660

Keywords

Keloid, Botulinum toxin, Methotrexate, Verapamil

Authors

First Name

Mohamed

Last Name

Reihan

MiddleName

Ahmed Galal

Affiliation

Abou Kir General Hospital, Alexandria, Egypt

Email

doc.moh.rehan@gmail.com

City

Alexandria

Orcid

-

First Name

Mostafa

Last Name

Meky

MiddleName

Sayed Ahmed

Affiliation

Plastic and Burn Surgery Department, Al-Azhar University.

Email

mostafamikki@hotmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Fareed

MiddleName

Mahmoud

Affiliation

Plastic and Burn Surgery Department Al-Azhar University

Email

dmohammedfareed811@gmail.com

City

-

Orcid

-

Volume

3

Article Issue

3

Related Issue

32736

Issue Date

2022-03-01

Receive Date

2021-11-19

Publish Date

2022-03-01

Page Start

110

Page End

114

Print ISSN

2682-3381

Online ISSN

2682-339X

Link

https://aimj.journals.ekb.eg/article_226868.html

Detail API

https://aimj.journals.ekb.eg/service?article_code=226868

Order

17

Type

Original Article

Type Code

710

Publication Type

Journal

Publication Title

Al-Azhar International Medical Journal

Publication Link

https://aimj.journals.ekb.eg/

MainTitle

Evaluation Of Intralesional Injection Of Botulinum Toxin Type A, Methotrexate, And Verapamil In Treatment Of Keloids: A Preliminary Study

Details

Type

Article

Created At

22 Jan 2023